[No.NP892-061] iMatrix 221 (350 ug: 175 ug × 2 tube/box)
Recombinant Laminin-221 E-8 Fragments
iMatrix-221’s features make it an ideal matrix for some cell culture applications:
- Xeno-free formulation / CHO-S cell bioproduction
- Easy to use (liquid format)
- E8-fragments retain integrin binding specificity and capacity, and display higher potency than natural Laminin-221
iMatrix-221 is a highly purified and refined product of human recombinant laminin-221 (E8 fragment) expressed by CHO-S cells. Laminin-221 is found predominantly in the basal lamina of striated muscle tissues. Expression deficiencies are implicated in muscular dystophy and cardiomyopathies.1
Laminins of the α-2 type are also a predomiant form found in the human adult heart tissue.2 Cultivation of iPSC-drived cardiomyocytes on iMatrix-221 has been demonstrated to maintain strong contractility in attached monolayer culture.3
SPECIFICATION
Product Name
iMatrix-221 Cardiac and Myoblast Cell Culture Substrate
Catalog Number
NP892-061
NP892-062
Size
- NP892-061 — 2 × 175 µg
- NP892-062 — 6 × 175 µg
Molecular Weight
150 kDa
Purity
>95% pure
Formulation
Purified Laminin-221 E8 proteolytic fragment
Storage and Stability
Store at 4 °C and protect from light exposure. Stable for 2 years from manufacturing date.
Quality Control
Activity: Kd for integrin binding
Sterility
Sterile
Notice To Purchaser
REPROCELL is a licensed distributor of Matrixome cell culture substrates to the global market.
Recommended Usage
iMatrix-221 is suitable for use as a substrate for culture of various myoblast cell types, but most notably for cardiomyocytes.
Concentration
500 µg/mL
Source
CHO-S cell expression
Manufacturer
Matrixome Corporation (Japan)
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