[No.04-0005] Sodium Butyrate

Sodium butyrate is the sodium salt of the short-chain fatty acid butyric acid. It is a metabolite of intestinal bacteria, a major energy source for gut epithelial cells, and is known to play a key role in the homeostasis of the gastrointestinal tract1. Sodium butyrate is also a known inhibitor of histone deacetylases (HDACs)2. HDAC inhibitors are promising anti-tumour agents that work by inhibiting cell proliferation and survival3. Along with the cytokines Activin A and acidic fibroblast growth factor (aFGF), sodium butyrate has been shown to direct the differentiation of mouse embryonic stem (ES) cells into hepatocytes4. Sodium butyrate has also been reported to increase the efficiency of transfection and expression for both transient and stable transfections5.

More information: reprocell.com