[No.04-0010-05] SB431542 (5 mg in solution (10 mM))
SB431542 is an inhibitor of the transforming growth factor-β 1 (TGFβ1) activin receptor-like kinases (ALKs). It is a selective and potent inhibitor of ALK-4, -5 and -7. SB431542 inhibits endogenous activin and TGFβ signaling without affecting more divergent BMP signaling utilizing ALK-1, -2, -3, and -61,2. SB431542 stimulates proliferation, differentiation, and sheet formation of endothelial cells derived from embryonic stem cells3.
More information: reprocell.com
SPECIFICATION
Product Name: Stemolecule SB431542
Catalog Number: 04-0010-base
Size:
- 10 mg (Cat. No. 04-0010-10)
- 5 mg (Cat. No. 04-0010)
- 5 mg at 10 mM in DMSO (04-0010-05)
Alternate Name(s): 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Chemical Formula: C22H16N4O3
Molecular Weight: 384.4
CAS Number: 301836-41-9 (anhydrous)
Purity: Greater than 98 % by HPLC analysis
Formulation: White solid
Solubility: Reconstitute in DMSO to the desired concentration. For reconstitution instructions please reference product specifications sheet.
Storage and Stability: Store powder at 4 °C protected from light. Information about the stability of Stemolecules in solution is largely not available. As a general guideline, we recommend that stock solution be freshly made and stored in aliquots at −20 °C, protected from light. The effect of storage of stock solutions should be verified for each application.
Quality Control: The purity of SB431542 was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. Cellular toxicity of SB431542 was tested on mouse embryonic stem cells.
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