[No.09-0014] StemAb SSEA-3 Antibody (Purified), Rat anti-Mouse/Human (100 uL)

The SSEA-3 monoclonal antibody reacts with stage-specific embryonic antigen-3 (SSEA-3), a carbohydrate epitope on the major ganglioside that is expressed upon the surface of human embryonal carcinoma (EC) cells, embryonic germ (EG) cells, and pluripotent stem (PS) cells. The expression of SSEA-3 on human PS cells is down-regulated upon differentiation. In mouse, SSEA-3 is expressed on unfertilized eggs and preimplantation to early cleaved embryos, and no immunoreactivity is evident in undifferentiated murine EC, ES, and EG cells. SSEA-3 antibody can be used to characterize human ES cells and monitor their differentiation.